Cyclobenzaprine Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Hepatic Dose Drug Index

A Flexeril overdose can cause severe health problems such as cardiac arrest, dangerously low blood pressure, and seizures. Central nervous system depression, seizures, heart attack, and even death can occur. Cyclobenzaprine comes as a tablet and an extended-release capsule to take by mouth. The extended-release capsule is usually taken with or without food once a day. Do not take this drug for more than 3 weeks without talking to your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

It is possible to overdose on cyclobenzaprine, which can lead to dangerous symptoms. One of those is rhabdomyolysis, which is the breakdown of muscle tissue from toxins that the kidneys can no longer process. The condition can also be caused by damage to the muscle fibers directly, causing them to break down and release their contents into the blood.

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A doctor will typically prescribe 5 mg of cyclobenzaprine, three times per day. Since Flexeril is a muscle relaxant that shows the depressive activity of the CNS, it is not recommended to drive or do any dangerous activity under the influence of Flexeril. Combining this drug with alcohol may worsen the side effects you may observe. Modifying the drug dose without consulting a physician to amplify its impact is also not recommended.

Mechanism(s) Of Action

While its exact mechanism of action remains unclear, scientists believe Robaxin can help with pain and discomfort caused by musculoskeletal conditions by blocking the pain signals that are sent to the brain. It is also believed that Robaxin relaxes the muscle by having depressive effects on the central nervous system. Flexeril is a strong muscle relaxant used with rest and physical therapy to treat muscle spasms. However, it is only for short-term relief from acute muscle pain and other skeletal conditions. It works by directly reducing muscle hyperactivity and decreasing the transmission of pain.

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Also, cyclobenzaprine can cause dry mouth because it has anticholinergic effects. As mentioned above, there is not a significant difference between Robaxin, Fexmid, Amrix, and other muscle relaxants in terms of efficacy in treating acute low back pain, other musculoskeletal pain, and muscle spasms. Clinicians should monitor for signs and symptoms of serotonin syndrome if the patient is taking other serotonergic drugs.

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We present this case as an example of the range of cyclobenzaprine toxicity and underline the treatment protocols used. For a thorough understanding of potential side effects, please consult a physician. Another rare side effect is an allergic reaction to the drug, manifested by hives and trouble breathing. We may receive advertising fees if you follow links to promoted online therapy websites.

• These feelings may potentially be a cause for misuse of Flexeril and lead to addictive effects.
• The use of significant lower dosing schedules in elderly patients may be prudent.
• Since the drug acts on the brain instead of the spinal cord or muscles, it is a good treatment for overall pain problems.
• Cyclobenzaprine is related structurally and pharmacologically to the tricyclic antidepressants (TCAs).

It is structurally similar to Amitryptilline, differing by only one double bond. Cyclobenzaprine is a weak inhibitor of presynaptic norepinephrine and serotonin. Skeletal muscle relaxant activity is due to brainstem mediated inhibition of gamma motor neurons.

For best results, doctors recommend combining the use of Flexeril with rest and physical therapy. Another potential side effect of Flexeril is overdose if an individual takes too much of the drug. Although Flexeril doesn’t produce a euphoric high like many other drugs, people still misuse it due to its relaxing effects; many will increase dosages to amplify those effects.

Do not take more or less of it or take it more often than prescribed by your doctor. Both cyclobenzaprine and methocarbamol have depressive effects on the central nervous system and can interact with other drugs that have a similar effect, such as benzodiazepines, opiate pain medications, and antidepressants. When these drugs interact, it can worsen side effects like drowsiness and dizziness. Skeletal muscle relaxants like cyclobenzaprine and methocarbamol can cause dizziness and drowsiness. Therefore, you should wait and see how these medications affect you before driving a motor vehicle or operating machinery. The other dosage form of this medicine is an injection solution into a muscle or into a vein.

People with heart conditions, especially previous heart attacks, blockages, heart rhythm issues, or congestive heart failure, should not take cyclobenzaprine. Cyclobenzaprine was approved for prescription use in the United States can flexeril help anxiety by the Food and Drug Administration (FDA) in 1977, and it is not currently listed on any Schedule as part of the Controlled Substances Act. However, it is still a drug that is diverted for nonmedical or recreational abuse.