Ingredients and Clinical Studies

Migraine Treatment Group

The Migraine Support Formula is the most advanced and clinically backed formula on the market for helping to reduce migraine headaches. Each of our ingredients has been shown through numerous studies to positively impact those who suffer from migraines. Each ingredient goes through rigorous testing standards to ensure its potency and safety. Each daily dose of the Migraine Support Formula contains the ingredients listed below. You will also find links to clinical studies related to each ingredient.

All links will open a new window directly to the government website for the National Center for Biotechnology Information.

Riboflavin (vitamin B2)

Evidence indicates that impaired mitochondrial oxygen in the brain plays a role in the pathology of migraine headaches. Vitamin B2 is essential to tissue respiration and generation of energy metabolism from proteins, carbs and fats. Riboflavin is also vital to help convert tryptophan to B3 (Niacin).

Two important randomized, double-blind, placebo controlled trials examined the effect of 400mg of riboflavin a day for three months on migraine reduction in 54 men and women and twenty three men and women with a history of recurring migraine headaches. Riboflavin was significantly better than a placebo in reducing attack frequency and number of attacks, especially during the third month of treatment. (Dept. of Neurology, Univ. of Liege, CHR Citadelle, Belgium and Dept. of Neurology, Charite, Humbolt Univ. of Berlin.)

The RDA for riboflavin is 1.3 mg/day. The Migraine Support Formula contains a whopping dose of 400 mg of riboflavin a day. No toxic or adverse effects of high riboflavin intake are known in humans.

Clinical Studies:


Individuals who suffer from recurring migraines often have lower magnesium levels.

Oral magnesium supplementation has been shown to increase intracellular magnesium levels in people with migraines. Doses of magnesium have been used effectively in the prophylaxis of migraines, in combination with riboflavin and in some cases, a supplement of coenzyme Q10. (Erciyes University, Medicine Faculty, Neurology Dept., Kayseri, Turkey.)

Doses higher than 300 mg of magnesium have been found to have adverse effects and are used medically as a saline laxative and may cause diarrhea and gastric irritation, so we chose to keep the dosage at 280 mg/day to counterbalance this reaction. Not only that, we use a combination of 5 different types of magnesium, including chelated, to increase absorption and reduce gastrointestinal discomfort. We use the following forms of magnesium in our formula: citrate, taurinate, malate, glycinate, and succinate.

Clinical Studies:


This plant is a popular herbal remedy often advocated for the reduction of migraines. Feverfew helps migraines by inhibiting the release of blood vessel dilating substances from platelets and inhibiting the production of inflammatory substances. Migraine Support Formula includes a large dose of 100 mg/day.

Numerous double blind placebo controlled trials have been conducted on this herb. Treatment with feverfew was associated with reduced vomiting and a reduction in the mean number and severity of attacks in many of these studies. Visual analogue scores also showed an improvement with feverfew. There were no serious side-effects and no major safety problems. (Dept. of Medicine, University Hospital, Nottingham and Dept. of Complementary Medicine, Univ. of Exeter Postgraduate Medicine and Health Science, UK.)

Clinical Studies:


This potent herb has been shown effective for reducing migraine headaches. Using a specific PA free extract of 75 mg from the butterbur root over 16 weeks can reduce the number and severity of migraine headaches by almost half.

An important clinical trial conducted by Department of Neurology, Albert Einstein College of Medicine concluded that butterbur is well tolerated and an effective therapy for migraines. The Department of Neurology, University of Essen, Germany also performed a double-blind and placebo-controlled clinical trial and concluded that migraine attacks could maximally be reduced by 52% in the butterbur group.

Butterbur is an herb that naturally contains a toxin called pyrrolizidine alkaloids (PAs). PA’s can damage the liver and cause other bodily harm over time. The Migraine Support Formula uses a certified PA free form of butterbur that completely removes PA’s and provides an ultra pure form of this ingredient.

Clinical Studies:


Ginger has been shown to decrease pain and scientists have discovered nine compounds found in ginger which bind to human serotonin receptors, helping to reduce triggers that cause migraines.

Ginger has been found effective in multiple studies for treating nausea. Migraine Support Formula contains a large 300 mg/day dose. Several clinical trials have been performed using feverfew and ginger in the treatment of migraines. The conclusion states “Sublingual feverfew/ginger appears safe and effective as a first-line abortive treatment for a population of migraineurs who frequently experience mild headache prior to the onset of moderate to severe headache.” (Headache Care Center, Springfield MO.)

Clinical Studies:

Coenzyme Q10

CoQ10 is an oil-soluble, vitamin like substance and is present in most eukaryotic cells, primarily in the mitochondria. Supplementation with coenzyme Q10 has been found beneficial for sufferers of migraines. Our formula uses 175 MG per day.

CoQ10 promotes energy generation in the body in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. Three studies have been done using 100 mg/day and found statistically significant results, especially in combination with a daily supplement of magnesium citrate and riboflavin. (Dept. of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Second Univ. of Naples, Italy.)

Clinical Studies:

Ginko Biloba

This important antioxidant is known for its ability to improve circulation both in the body and brain. One of the most popular herbal remedies in the world, ginko biloba has been used for migraine headache symptoms and helps to inhibit platelet aggregation.

Ginko contains flavonoids and terpenoids. Migraine Support Formula contains 120 mg/day. Two French clinical trials have been conducted and found that the total number of migraine attacks were reduced significantly and may be beneficial in helping migraines due to its ability to inhibit platelet activating factor.

Clinical Studies:

White Willow Bark Extract (Salix Alba)

This natural extract contains the active ingredient called salicin, which is a precurser to aspirin. Salicin is a Cox-1 and Cox-2 inhibitor, and acts as an anti-inflammatory and also reduces pain by inhibiting prostaglandins.

One recent study indicated that white willow bark and feverfew had a greater effect at reducing migraines than when taken separately. Several countries in Europe including The German Commission E and The European Scientific Cooperative on Phytotherapy have approved willow bark extract as an analgesic to treat fever and pain.

Clinical Studies:

Vitamin B3 (Niacin)

Niacin is water soluble and is crucial to about 50 chemical reactions in the body. It helps in the release of energy from carbohydrates, fats and cholesterol metabolism and the regulation of blood sugar levels. 50% of niacin in the body comes from the conversion of tryptophan.

Niacin sometimes causes a flushing of the face and in the process flushes the migraine away. This is something that the pharmaceutical industry does not want known. The migraine support formula provides 60 mg/day. Studies from as early as 1944 show that niacin was effective in the relief of migraines.

In one study, 81% of headache sufferers reported positive results when using niacin and in another study 75% had complete headache relief when given niacin. (Velling DA, Dodick DW, Muir JJ. Sustained-release niacin for prevention of migraine headache. Mayo Clin Proc.)

Clinical Studies:

Vitamin B6 (Pyridoxine)

B6 helps in the production of serotonin, histamine and dopamine. B6 works to reduce migraine headaches as a result of its role in histamine function.

Most people take in more B6 blockers such as food coloring, birth control pills, excessive protein, alcohol and other things that block the B6 itself. B6 supplements have shown to relieve histamine-induced headaches by increasing diamine oxidase activity. B6 assists the body in the accumulation of magnesium.

Clinical Studies:


BioPerine is our secret ingredient. The extract of piperine, called BioPerine in the patented form, has been clinically tested in the United States. BioPerine significantly enhances the bio-availability of various supplement nutrients through increased absorption.

In clinical trials, BioPerine increased nutrient absorbtion in patients by as much as 60%. This allows each ingredient in our formula to be fully absorbed and utilized where it is needed most.

Clinical Studies: